The STON1 Antibody (PACO02388) is a high-quality polyclonal antibody designed for research involving STON1, a key protein involved in membrane trafficking and autophagy processes. This antibody, raised in rabbits, is highly specific and reactive with human samples, making it ideal for use in various experimental applications.STON1, also known as stonin-1, plays a crucial role in the sorting and trafficking of vesicles within cells, particularly in the endocytic pathway. By binding to STON1, this antibody enables researchers to study the dynamics and localization of STON1 in different cellular contexts, providing valuable insights into its function and regulation.
The STON1 Antibody is validated for use in techniques such as Western blotting and immunofluorescence, allowing for precise detection and visualization of STON1 in cell lysates or tissue samples. Its versatility and reliability make it a valuable tool for studies in cell biology, molecular biology, and neurobiology, furthering our understanding of membrane trafficking processes and autophagy mechanisms.
Antibody Name:
STON1 Antibody
Antibody SKU:
PACO02388
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC, IF
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the C-terminal region of human Stonin-1.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
STON1: May be involved in the endocytic machinery. Belongs to the Stoned B family.Chromosomal Location of Human Ortholog: 2p16.3Cellular Component: clathrin adaptor complexBiological Process: intracellular protein transport; regulation of endocytosis; endocytosis
UniProt Protein Details:
NCBI Summary:
Endocytosis of cell surface proteins is mediated by a complex molecular machinery that assembles on the inner surface of the plasma membrane. This gene encodes one of two human homologs of the Drosophila melanogaster stoned B protein. This protein is related to components of the endocytic machinery and exhibits a modular structure consisting of an N-terminal proline-rich domain, a central region of homology specific to the human stoned B-like proteins, and a C-terminal region homologous to the mu subunits of adaptor protein (AP) complexes. Read-through transcription of this gene into the neighboring downstream gene, which encodes TFIIA-alpha/beta-like factor, generates a transcript (SALF), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]
