The STOML3 Antibody (PAC05250) is a valuable tool for researchers studying STOML3, a protein involved in mitochondrial membrane dynamics and regulation. This polyclonal antibody, generated in rabbits, exhibits high reactivity with human samples and is suitable for Western blot applications. By specifically binding to STOML3, this antibody enables the detection and analysis of the protein in various cell types, making it an ideal choice for investigations in the fields of mitochondria biology and neurodegenerative diseases.STOML3, also known as stomatin-like protein 3, plays a crucial role in maintaining mitochondrial morphology and function, impacting cellular processes such as metabolism, apoptosis, and cell signaling.
Dysregulation of STOML3 has been linked to neurological disorders like Alzheimer's disease and Parkinson's disease, making it a promising target for therapeutic interventions. By gaining a deeper understanding of STOML3's functions, researchers can potentially uncover new treatment strategies for these conditions and other related diseases.
Western Blot. Positive WB detected in: Rat brain tissue, Mouse brain tissue. All lanes: STOML3 antibody at 3.4µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 33, 32 kDa. Observed band size: 40 kDa.
Immunohistochemistry of paraffin-embedded human ovarian cancer using PACO52650 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human lung cancer using PACO52650 at dilution of 1:100.
Background:
Required for the function of many mechanoreceptors. Modulate mechanotransduction channels and acid, sensing ion channels (ASIC) proteins. Potentiates PIEZO1 and PIEZO2 function by increasing their sensitivity to mechanical stimulations.
Synonyms:
Stomatin-like protein 3 (SLP-3), STOML3
UniProt Protein Function:
STOML3: Belongs to the band 7/mec-2 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 13q13.3
