The STK39 Polyclonal Antibody (CAB7974) is a valuable tool for research involving STK39, a serine/threonine kinase that plays a role in regulating ion transport and blood pressure. This antibody, raised in rabbits, is highly specific for human samples and is validated for use in Western blot applications. It effectively binds to the STK39 protein, allowing for accurate detection and analysis in a variety of cell types.STK39, also known as SPAK, is a key player in the regulation of ion transport processes in the kidney, making it a promising target for studies related to hypertension and other cardiovascular conditions.
By understanding the function and activity of STK39, researchers can gain insights into its role in blood pressure regulation and potentially discover new therapeutic targets for cardiovascular diseases.Overall, the STK39 Polyclonal Antibody is an essential tool for researchers interested in investigating the roles and functions of STK39 in human physiology and disease. Its high specificity and sensitivity make it an ideal choice for studies in the fields of cardiovascular research and hypertension.
Product Name:
STK39 Rabbit Polyclonal Antibody
SKU:
CAB7974
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 500-600 of human STK39 (Q9UEW8).
Sequence:
VAAN LQKI VDDP KALK TLTF KLAS GCDG SEIP DEVK LIGF AQLS VS
Tested Applications:
WBELISA
Recommended Dilution:
WB,1:500 - 1:2000
Synonyms:
DCHT; PASK; SPAK; STK39
Positive Sample:
HT-29,PC-12,Mouse testis,Mouse brain
Conjugate:
Unconjugated
Cellular Localization:
Cytoplasm, Nucleus.
Calculated MW:
59kDa
Observed MW:
59kDa
This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress.
Purification Method:
Affinity purification
Gene ID:
27347
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using STK39 antibody (CAB7974) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
