The STK11 Polyclonal Antibody (CAB2122) is a valuable tool for researchers studying the STK11 protein, also known as LKB1, which is a key regulator of cell growth, metabolism, and polarity. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the STK11 protein, this antibody allows for the accurate detection and analysis of STK11 expression in a variety of cell types, making it ideal for studies in cancer biology, metabolism, and cellular signaling pathways.STK11/LKB1 is a crucial tumor suppressor that is frequently mutated or inactivated in cancer, leading to uncontrolled cell growth and proliferation.
Research into STK11's role in cellular processes and its interactions with other signaling molecules is essential for developing targeted therapies for cancer treatment. The STK11 Polyclonal Antibody provides researchers with a reliable tool to investigate the function of STK11 in both normal and diseased cells, offering valuable insights into potential therapeutic strategies for cancer and other related diseases.
Product Name:
[KO Validated] LKB1 Rabbit Polyclonal Antibody
SKU:
CAB2122
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 134-433 of human LKB1 (NP_000446.1).
The protein encoded by this gene is a serine/threonine kinase that regulates cell polarity and energy metabolism and functions as a tumor suppressor. Mutations in this gene have been associated with the autosomal dominant Peutz-Jeghers syndrome, as well as with skin, pancreatic, and testicular cancers.
Purification Method:
Affinity purification
Gene ID:
6794
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using LKB1 Rabbit pAb (CAB2122) at 1:600 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
