The STIP1 Polyclonal Antibody (CAB1219) is a valuable tool for researchers studying STIP1, a protein involved in cellular processes such as protein folding and trafficking. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the STIP1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential component for studies in cell biology and molecular biology.STIP1, also known as stress-induced phosphoprotein 1, plays a crucial role in coordinating protein folding and transport within cells, making it a key player in maintaining cellular homeostasis.
Its involvement in these processes highlights its importance in various physiological and pathological conditions, such as neurodegenerative diseases and cancer. By unraveling the mechanisms of STIP1 action, researchers can gain insights into disease pathogenesis and potentially identify new therapeutic targets for intervention. Understanding the functions of STIP1 is essential for advancing knowledge in cell biology and developing novel approaches for disease treatment.
Product Name:
STIP1 Rabbit Polyclonal Antibody
SKU:
CAB1219
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human STIP1 (NP_006810.1).
STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).
Purification Method:
Affinity purification
Gene ID:
10963
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using STIP1 Rabbit pAb (CAB1219) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
