The TMEM173 Polyclonal Antibody (CAB3575) is a valuable tool for researchers studying the TMEM173 protein, also known as Stimulator of Interferon Genes (STING), which plays a crucial role in the innate immune response to viral and bacterial infections. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.TMEM173 is a key mediator of the immune response, activating the production of interferons and other immune signaling molecules in response to cytosolic DNA. Dysregulation of the STING pathway has been implicated in various diseases, including autoimmune disorders, infectious diseases, and cancer.
By detecting and analyzing the TMEM173 protein, researchers can gain insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets.The TMEM173 Polyclonal Antibody is an essential tool for immunologists and cancer researchers looking to delve deeper into the intricate workings of the immune system and develop novel treatments for a range of diseases. Its high specificity and sensitivity make it a reliable option for studying TMEM173 in various cell types and experimental settings.
Product Name:
STING/TMEM173 Rabbit Polyclonal Antibody
SKU:
CAB3575
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 139-379 of human STING/TMEM173 (NP_938023.1).
This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
340061
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.09% Sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using STING/TMEM173 Rabbit pAb (CAB3575) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
