The STIM2 Polyclonal Antibody (CAB17743) is a valuable tool for researchers studying STIM2, a key regulator of calcium signaling in immune and non-immune cells. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the STIM2 protein, this antibody enables precise detection and analysis in various cell types, making it ideal for investigations in immunology, neuroscience, and cancer research.
STIM2 is known for its role in controlling calcium entry into cells, a process essential for various cellular functions like gene expression, cell proliferation, and immune responses. Dysregulation of STIM2 signaling has been implicated in diseases such as autoimmune disorders, neurodegenerative conditions, and certain types of cancer. Therefore, exploring the function of STIM2 using this antibody may provide valuable insights for developing targeted therapies in these disease settings.
Product Name:
STIM2 Rabbit Polyclonal Antibody
SKU:
CAB17743
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 60-180 of human STIM2 (NP_001162588).
Endoplasmic reticulum membrane, Single-pass type I membrane protein.
Calculated MW:
84kDa
Observed MW:
110kDa
This gene is a member of the stromal interaction molecule (STIM) family and likely arose, along with related family member STIM1, from a common ancestral gene. The encoded protein functions to regulate calcium concentrations in the cytosol and endoplasmic reticulum, and is involved in the activation of plasma membrane Orai Ca(2+) entry channels. This gene initiates translation from a non-AUG (UUG) start site. A signal peptide is cleaved from the resulting protein. Multiple transcript variants result from alternative splicing.
Purification Method:
Affinity purification
Gene ID:
57620
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from 293T cells, using STIM2 Rabbit pAb (CAB17743) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
