The STIM1 Polyclonal Antibody is a vital tool for researchers studying STIM1, a key protein involved in calcium signaling pathways essential for immune responses. This antibody, produced in rabbits, displays high reactivity with human samples and has been validated for use in Western blot applications. By binding to STIM1, this antibody enables precise detection and analysis of the protein in various cell types, making it perfect for studies in immunology, cell biology, and cancer research.STIM1 is a pivotal component of the store-operated calcium entry (SOCE) pathway, which is crucial for orchestrating immune cell function, inflammation, and cell proliferation.
Dysregulation of STIM1 signaling has been implicated in autoimmune diseases, allergies, and cancer, highlighting its importance as a potential therapeutic target. By elucidating the role of STIM1 in these conditions, researchers can pave the way for the development of novel treatment strategies that target calcium signaling pathways.
Product Name:
STIM1 Polyclonal Antibody
SKU:
CAB21614
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 451-685 of human STIM1 (NP_003147.2).
WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Synonyms:
GOK; TAM; TAM1; IMD10; STRMK; D11S4896E; STIM1
Positive Sample:
HeLa
Conjugate:
Unconjugated
Cellular Localization:
Cell membrane, Cytoplasm, Endoplasmic reticulum membrane, Single-pass type I membrane protein, cytoskeleton.
Calculated MW:
77kDa
Observed MW:
Refer to figures
This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. Mutations in this gene are associated with fatal classic Kaposi sarcoma, immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts, ectodermal dysplasia and tubular aggregate myopathy. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene. Alternative splicing of this gene results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
6786
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded mouse brain using STIM1 Rabbit pAb (CAB21614) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
