The STEAP4 Polyclonal Antibody (CAB17767) is a valuable tool for research involving the STEAP4 protein, a transmembrane protein that plays a key role in iron homeostasis and cellular metabolism. This antibody, generated in rabbits, has high specificity and sensitivity for detecting STEAP4 in human samples and is validated for use in Western blot applications.STEAP4, also known as six-transmembrane epithelial antigen of the prostate 4, is involved in the regulation of cellular iron uptake and storage, making it a potential target for studying iron metabolism and its implications in various diseases.
Research on STEAP4 can provide insights into conditions such as iron deficiency, anemia, and cancer, where dysregulation of iron metabolism plays a role in disease progression.Using the STEAP4 Polyclonal Antibody, researchers can accurately detect and analyze STEAP4 expression in different cell types and tissues, contributing to a better understanding of its function and potential therapeutic applications. This antibody is an essential tool for studies in the fields of metabolism, oncology, and iron-related disorders.
Product Name:
STEAP4 Rabbit Polyclonal Antibody
SKU:
CAB17767
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human STEAP4 (NP_001192245).
The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
79689
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using STEAP4 Rabbit pAb (CAB17767) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
