The Steap2 Polyclonal Antibody (PACO03820) is an essential tool for researchers studying the STEAP2 protein, a member of the six-transmembrane epithelial antigen of prostate (STEAP) family. This antibody, produced in rabbits, shows high reactivity with human samples and has been validated for use in various applications, including Western blot and immunohistochemistry.STEAP2 is known to play a crucial role in regulating cellular iron metabolism and is associated with various disease processes, including cancer and iron-related disorders. By targeting the STEAP2 protein, researchers can investigate its functions in different cell types and tissues, providing valuable insights into its role in disease development and progression.
The Steap2 Polyclonal Antibody is a valuable tool for studying the molecular mechanisms underlying STEAP2 function and its potential as a therapeutic target in various pathological conditions. Its specificity and reliability make it an ideal choice for immunology and cancer research studies aimed at understanding the role of STEAP2 in human health and disease.
Antibody Name:
STEAP2 Antibody
Antibody SKU:
PACO03820
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC, IF
Recommended Dilutions:
IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from the C-terminal region of human STEAP2.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
STEAP2; PCANAP1; STAMP1; Metalloreductase STEAP2; Prostate cancer-associated protein 1; Protein up-regulated in metastatic prostate cancer; PUMPCn; Six-transmembrane epithelial antigen of prostate 2; SixTransMembrane protein of prostate 1
UniProt Protein Function:
STEAP2: Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Belongs to the STEAP family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Oxidoreductase; EC 1.16.1.-; Membrane protein, integral; Vesicle; Membrane protein, multi-passChromosomal Location of Human Ortholog: 7q21.13Cellular Component: trans-Golgi network transport vesicle; intracellular membrane-bound organelle; early endosome; plasma membrane; integral to Golgi membrane; endosome membrane; cytosolMolecular Function: transporter activity; metal ion binding; cupric reductase activityBiological Process: regulated secretory pathway; Golgi to plasma membrane transport; iron ion homeostasis; response to hormone stimulus; copper ion import; endocytosis
UniProt Protein Details:
NCBI Summary:
This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Prostate cancer-associated protein 1; Protein up-regulated in metastatic prostate cancer; PUMPCn; Six-transmembrane epithelial antigen of prostate 2; SixTransMembrane protein of prostate 1
