The Staufen Homolog 1 (STAU1) Polyclonal Antibody (CAB4131) is a valuable tool for research involving STAU1, a protein involved in various cellular processes, including mRNA transport and RNA degradation. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.STAU1 is known for its role in post-transcriptional regulation of gene expression, making it a key player in cellular responses to stress and differentiation. Its interaction with mRNA molecules allows for the regulation of protein synthesis and turnover, influencing cell function and development.
Research into STAU1 is essential for understanding how cells respond to environmental cues and maintain homeostasis. By targeting STAU1, scientists can uncover new insights into gene expression regulation and potentially identify new therapeutic targets for diseases such as cancer and neurodegenerative disorders. This antibody provides a reliable tool for studying STAU1 and its functions in various cell types, making it ideal for investigations in molecular biology and cell biology.
Product Name:
Staufen Rabbit Polyclonal Antibody
SKU:
CAB4131
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 426-577 of human Staufen (NP_059347.2).
Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation.
Purification Method:
Affinity purification
Gene ID:
6780
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using Staufen Rabbit pAb (CAB4131) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
