STAT5B Polyclonal Antibody (CAB21613)
- SKU:
- CAB21613
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- IHC
- IP
- IF
Description
Product Name: | STAT5B Polyclonal Antibody |
SKU: | CAB21613 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 586-787 of human STAT5B (NP_036580.2). |
Sequence: | KPHW NDGA ILGF VNKQ QAHD LLIN KPDG TFLL RFSD SEIG GITI AWKF DSQE RMFW NLMP FTTR DFSI RSLA DRLG DLNY LIYV FPDR PKDE VYSK YYTP VPCE SATA KAVD GYVK PQIK QVVP EFVN ASAD AGGG SATY MDQA PSPA VCPQ AHYN MYPQ NPDS VLDT DGDF DLED TMDV ARRV EELL GRPM DSQW IPHA QS |
Tested Applications: | WB IHC-P IF/ICC IP ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IP,0.5μg-4μg antibody for 400μg-600μg extracts of whole cellsIF/ICC,1:50 - 1:200 |
Synonyms: | STAT5; GHISID2; 5B |
Positive Sample: | HeLa,Mouse liver,Mouse heart,Mouse thymus,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 90kDa |
Observed MW: | 92kDa |
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.
Purification Method: | Affinity purification |
Gene ID: | 6777 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |