The STAT5B Polyclonal Antibody is a crucial tool for researchers studying the STAT5B protein, a key player in signaling pathways that regulate cell proliferation, differentiation, and survival. This antibody, generated in rabbits, is highly specific for STAT5B in human samples and has been validated for use in Western blotting applications.STAT5B is a transcription factor that plays a critical role in various cellular processes, including immune response, hematopoiesis, and cancer development. By binding to STAT5B, this antibody enables precise detection and analysis of the protein in a variety of cell types, making it an essential tool for studies in immunology, oncology, and beyond.
Understanding the function of STAT5B is vital for unraveling its role in disease processes such as cancer, autoimmune disorders, and metabolic conditions. Research using the STAT5B Polyclonal Antibody may lead to important insights that could ultimately drive the development of targeted therapies for these conditions.
Product Name:
STAT5B Polyclonal Antibody
SKU:
CAB21613
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 586-787 of human STAT5B (NP_036580.2).
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.
Purification Method:
Affinity purification
Gene ID:
6777
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using [KO Validated] STAT5B Rabbit pAb (CAB21613) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
