STAT5B Rabbit Polyclonal Antibody (CAB12356)
- SKU:
- CAB12356
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | STAT5B Rabbit Polyclonal Antibody |
SKU: | CAB12356 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 594-794 of human STAT5B (NP_003143.2). |
Sequence: | ILGF VNKQ QAHD LLIN KPDG TFLL RFSD SEIG GITI AWKF DSPE RNLW NLKP FTTR DFSI RSLA DRLG DLSY LIYV FPDR PKDE VFSK YYTP VLAK AVDG YVKP QIKQ VVPE FVNA SADA GGSS ATYM DQAP SPAV CPQA PYNM YPQN PDHV LDQD GEFD LDET MDVA RHVE ELLR RPMD SLDS RLSP PAGL FTSA RGSL S |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | STAT5; GHISID2; STAT5B |
Positive Sample: | HeLa,Mouse thymus |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 90kDa |
Observed MW: | 100kDa |
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.
Purification Method: | Affinity purification |
Gene ID: | 6777 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |