STAT5B Rabbit Polyclonal Antibody (CAB0275)
- SKU:
- CAB0275
- Product Type:
- Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | STAT5B Rabbit Polyclonal Antibody |
SKU: | CAB0275 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 40-280 of human STAT5B (NP_036580.2). |
Sequence: | SQAW DSVD LDNP QENI KATQ LLEG LVQE LQKK AEHQ VGED GFLL KIKL GHYA TQLQ NTYD RCPM ELVR CIRH ILYN EQRL VREA NNGS SPAG SLAD AMSQ KHLQ INQT FEEL RLVT QDTE NELK KLQQ TQEY FIIQ YQES LRIQ AQFG PLAQ LSPQ ERLS RETA LQQK QVSL EAWL QREA QTLQ QYRV ELAE KHQK TLQL LRKQ QTII LDDE LIQW KRRQ QLAG NGGP PEGS LDVL QSWC E |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:20 - 1:50 |
Synonyms: | STAT5; GHISID2; STAT5B |
Positive Sample: | K-562,PC-12,MCF7,HepG2 |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 90kDa |
Observed MW: | 95kDa |
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.
Purification Method: | Affinity purification |
Gene ID: | 6777 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |