The STAT5A/B Polyclonal Antibody (CAB17930) is a valuable tool for researchers studying signal transducer and activator of transcription (STAT) proteins, specifically STAT5A and STAT5B. These transcription factors play key roles in cell signaling pathways, controlling gene expression in response to various stimuli. Raised in rabbits, this antibody is highly specific and reactive with human samples, making it ideal for use in Western blot applications. It binds specifically to the STAT5A and STAT5B proteins, enabling the detection and analysis of these critical factors in various cell types.
Research involving STAT proteins has important implications in immunology, cancer research, and other disease contexts. By understanding the activity of STAT5A and STAT5B, researchers can make significant strides in developing targeted therapies for diseases such as cancer and autoimmune disorders. Overall, the STAT5A/B Polyclonal Antibody (CAB17930) is a valuable tool for any researcher investigating the role of STAT proteins in cell signaling and gene expression, providing crucial insights into the mechanisms underlying various diseases and potential therapeutic strategies.
Product Name:
STAT5A/STAT5B Rabbit Polyclonal Antibody
SKU:
CAB17930
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 700-787 of human STAT5A/STAT5B (NP_036580.2).
Carries out a dual signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.
Purification Method:
Affinity purification
Gene ID:
6776/6777
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse kidney, using STAT5A/STAT5B Rabbit pAb (CAB17930) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 30s.
