The STAT5A Polyclonal Antibody (CAB7733) is a valuable tool for research involving STAT5A, a key transcription factor involved in various cellular processes, including cell growth, differentiation, and survival. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting STAT5A protein in human samples, making it suitable for use in Western blot applications.STAT5A plays a crucial role in signal transduction pathways activated by cytokines and growth factors, regulating gene expression and cellular responses. Dysregulation of STAT5A has been implicated in various diseases, including cancer, autoimmune disorders, and inflammatory conditions. By targeting STAT5A, researchers can gain valuable insights into the molecular mechanisms underlying these conditions and potentially identify new therapeutic targets.
With its ability to specifically bind to STAT5A protein, the CAB7733 antibody enables accurate detection and analysis of STAT5A expression levels in different cell types, providing researchers with a powerful tool for investigating the role of STAT5A in physiological and pathological processes. Whether studying cell signaling pathways, developmental biology, or disease mechanisms, the STAT5A Polyclonal Antibody is a valuable resource for advancing scientific knowledge in the fields of immunology and cancer research.
Product Name:
STAT5A Rabbit Polyclonal Antibody
SKU:
CAB7733
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 635-794 of human STAT5A (NP_003143.2).
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
6776
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of HeLa cells, using STAT5A antibody (CAB7733) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
