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STAT5A Monoclonal Antibody (CAB21228)

SKU:
CAB21228
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
€139 - €529
Frequently bought together:

Description

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Product Name:STAT5A Monoclonal Antibody
SKU:CAB21228
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human STAT5A (NP_003143.2).
Sequence:MAGW IQAQ QLQG DALR QMQV LYGQ HFPI EVRH YLAQ WIES QPWD AIDL DNPQ DRAQ ATQL LEGL VQEL QKKA EHQV GEDG FLLK IKLG HYAT QLQK TYDR
Tested Applications:WB ELISA
Recommended Dilution:WB,1:10000 - 1:30000
Synonyms:MGF; STAT5; STAT5A
Positive Sample:K-562,PC-3,HeLa,Mouse liver
Conjugate:Unconjugated
Cellular Localization:Cytoplasm, Nucleus.
Calculated MW:91kDa
Observed MW:100kDa

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene.

Purification Method:Affinity purification
Gene ID:6776
Clone Number:ARC52814
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of various cell lines, using STAT5A antibody (CAB21228) at 1:20000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.

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