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STAT5A Rabbit Monoclonal Antibody (CAB5029)

SKU:
CAB5029
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:STAT5A Rabbit Monoclonal Antibody
SKU:CAB5029
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 600-786 of human STAT5 (P42229).
Sequence:KQQA HDLL INKP DGTF LLRF SDSE IGGI TIAW KFDS PERN LWNL KPFT TRDF SIRS LADR LGDL SYLI YVFP DRPK DEVF SKYY TPVL AKAV DGYV KPQI KQVV PEFV NASA DAGG SSAT YMDQ APSP AVCP QAPY NMYP QNPD HVLD QDGE FDLD ETMD VARH VEEL LRRP MDSL DSRL SPPA GLF
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:2000
Synonyms:MGF; STAT5
Positive Sample:HeLa,PC-3,Mouse heart,Rat lung
Conjugate:Unconjugated
Cellular Localization:Cytoplasm, Nucleus.
Calculated MW:90kDa
Observed MW:90kDa

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]

Purification Method:Affinity purification
Gene ID:6776/6777
Clone Number:ARC1215
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using STAT5 Rabbit mAb (CAB5029) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.

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