The STAT4 Polyclonal Antibody (CAB6991) is a valuable tool for researchers studying the STAT4 protein, a key regulator of immune responses and cell growth. This antibody, produced through rabbit immunization, has high specificity for human samples and is validated for use in Western blot applications. By binding to STAT4, the antibody allows for accurate detection and analysis in a variety of cell types, making it an essential component for studies in immunology and cancer research.STAT4 is a crucial signaling molecule involved in the activation of immune cells and the production of inflammatory cytokines.
Dysregulation of STAT4 signaling has been linked to various autoimmune diseases, cancer, and inflammatory conditions. Understanding the role of STAT4 in these diseases is essential for developing targeted therapies that modulate immune responses and cell growth pathways.Overall, the STAT4 Polyclonal Antibody is a reliable tool for researchers aiming to explore the complex functions of the STAT4 protein and its implications in human health and disease. Its high specificity and sensitivity make it a valuable asset for studies in the fields of immunology and cancer research.
Product Name:
STAT4 Rabbit Polyclonal Antibody
SKU:
CAB6991
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 569-748 of human STAT4 (NP_003142.1).
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein.
Purification Method:
Affinity purification
Gene ID:
6775
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from NCI-H460 cells, using STAT4 Rabbit pAb (CAB6991) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
