The STAT3 Rabbit Polyclonal Antibody (CAB16975) is a valuable tool for researchers studying the signal transducer and activator of transcription 3 (STAT3) protein. This antibody is raised in rabbits and is highly reactive with human samples, making it ideal for use in Western blot applications. By binding to STAT3, this antibody allows for the detection and analysis of this important transcription factor in various cell types.STAT3 is a critical regulator of cell growth, survival, and differentiation, with implications in cancer, inflammation, and immune response.
Understanding the activity and regulation of STAT3 is essential for unraveling its role in various disease processes and for developing targeted therapies. The STAT3 Rabbit Polyclonal Antibody is a reliable tool for researchers investigating the molecular mechanisms involving STAT3 in cancer biology, immunology, and other related fields.Order the STAT3 Rabbit Polyclonal Antibody (CAB16975) today to advance your research in STAT3 signaling and discover new insights into the role of this protein in health and disease.
Product Name:
STAT3 Rabbit Polyclonal Antibody
SKU:
CAB16975
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 130-770 of human STAT3 (NP_644805.1).
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. This gene also plays a role in regulating host response to viral and bacterial infections. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome.
Purification Method:
Affinity purification
Gene ID:
6774
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from A-549 cells, using STAT3 Rabbit pAb (CAB16975) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
