STAT3 Rabbit Polyclonal Antibody (CAB16975)
- SKU:
- CAB16975
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Product Name: | STAT3 Rabbit Polyclonal Antibody |
SKU: | CAB16975 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 130-770 of human STAT3 (NP_644805.1). |
Sequence: | NHPT AAVV TEKQ QMLE QHLQ DVRK RVQD LEQK MKVV ENLQ DDFD FNYK TLKS QGDM QDLN GNNQ SVTR QKMQ QLEQ MLTA LDQM RRSI VSEL AGLL SAME YVQK TLTD EELA DWKR RQQI ACIG GPPN ICLD RLEN WITS LAES QLQT RQQI KKLE ELQQ KVSY KGDP IVQH RPML EERI VELF RNLM KSAF VVER QPCM PMHP DRPL VIKT GVQF TTKV RLLV KFPE LNYQ LKIK VCID KDSG DVAA LRGS RKFN ILGT NTKV MNME ESNN GSLS AEFK HLTL REQR CGNG GRAN CDAS LIVT EELH LITF ETEV YHQG LKID LETH SLPV VVIS NICQ MPNA WASI LWYN MLTN NPKN VNFF TKPP IGTW DQVA EVLS WQFS STTK RGLS IEQL TTLA EKLL GPGV NYSG CQIT WAKF CKEN MAGK GFSF WVWL DNII DLVK KYIL ALWN EGYI MGFI SKER ERAI LSTK PPGT FLLR FSES SKEG GVTF TWVE KDIS GKTQ IQSV EPYT KQQL NNMS FAEI IMGY KIMD ATNI LVSP LVYL YPDI PKEE AFGK YCRP ESQE HPEA DPGS AAPY LKTK FICV TP |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | APRF; HIES; ADMIO; ADMIO1; STAT3 |
Positive Sample: | A-549,Rat kidney |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 88kDa |
Observed MW: | 79kDa |
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. This gene also plays a role in regulating host response to viral and bacterial infections. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome.
Purification Method: | Affinity purification |
Gene ID: | 6774 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |