The STAT3 Polyclonal Antibody (CAB11216) is a valuable tool for researchers studying the STAT3 protein, a key transcription factor involved in various cellular processes, including cell growth and survival. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. It specifically targets the STAT3 protein, allowing for accurate detection and analysis in a variety of cell types, making it ideal for investigations in areas such as immunology and cancer research.STAT3 is a critical signaling molecule that plays a pivotal role in regulating gene expression and cell function in response to various stimuli.
Dysregulation of STAT3 has been implicated in a wide range of diseases, including cancer, inflammation, and autoimmune disorders. By studying the activity of STAT3, researchers can gain insights into disease mechanisms and potentially identify new therapeutic targets for intervention.Overall, the STAT3 Polyclonal Antibody is a valuable tool for researchers seeking to better understand the role of STAT3 in health and disease, and it holds promise for further advancements in the fields of molecular biology and medicine.
Product Name:
STAT3 Rabbit Polyclonal Antibody
SKU:
CAB11216
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 600-700 of human STAT3 (NP_003141.2).
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. This gene also plays a role in regulating host response to viral and bacterial infections. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome.
Purification Method:
Affinity purification
Gene ID:
6774
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using STAT3 Rabbit pAb (CAB11216) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
