The STAR Polyclonal Antibody (CAB1035) is an essential research tool for studying the STAR protein, a key regulator of cholesterol and lipid metabolism. This antibody is raised in rabbits and is highly specific for human samples, making it ideal for use in Western blot applications. By binding to the STAR protein, researchers can effectively detect and analyze this important molecule in various cell types.STAR, also known as steroidogenic acute regulatory protein, plays a crucial role in controlling the synthesis of cholesterol and steroid hormones in the adrenal glands and gonads. Dysregulation of STAR has been linked to various metabolic disorders, making it a promising target for therapeutic interventions.
By studying the function of STAR, researchers can gain insights into lipid metabolism, hormone production, and potential disease mechanisms.The STAR Polyclonal Antibody is a valuable tool for researchers in the fields of endocrinology, metabolism, and lipid biology. Its high reactivity and specificity make it an essential component for studies aiming to unravel the molecular mechanisms underlying lipid metabolism and hormone production. Invest in the STAR Polyclonal Antibody (CAB1035) today and advance your research in cholesterol and lipid metabolism.
Product Name:
STAR Rabbit Polyclonal Antibody
SKU:
CAB1035
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 64-285 of human StAR (NP_000340.2).
WB,1:100 - 1:500 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Synonyms:
STARD1; StAR
Positive Sample:
HEL,K-562,Mouse testis
Conjugate:
Unconjugated
Cellular Localization:
Mitochondrion.
Calculated MW:
32kDa
Observed MW:
28kDa
The protein encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A pseudogene of this gene is located on chromosome 13.
Purification Method:
Affinity purification
Gene ID:
6770
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using StAR Rabbit pAb (CAB1035) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
