The STAP1 Polyclonal Antibody (PAC042342) is a valuable tool for researchers studying STAP1, a protein involved in various cellular processes, including signal transduction and immune regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the STAP1 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it an essential component for studies in immunology, cancer research, and beyond.STAP1, also known as signal transducing adapter family member 1, is a key player in cellular signaling pathways, influencing processes such as cell proliferation, differentiation, and survival.
Its importance in immune regulation suggests potential implications in diseases such as cancer, autoimmune disorders, and inflammatory conditions. By delving into the functions of STAP1, researchers can uncover novel insights into disease mechanisms and potentially identify new therapeutic targets for intervention.Overall, the STAP1 Polyclonal Antibody is a reliable tool for investigating the intricate roles of STAP1 in diverse physiological and pathological contexts, offering researchers the opportunity to deepen their understanding of cellular signaling and immune responses.
Antibody Name:
STAP1 Antibody (PACO42342)
Antibody SKU:
PACO42342
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Human
Immunogen:
Recombinant Human Signal-transducing adaptor protein 1 protein (1-295AA)
In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a positive feedback loop by increasing the activity of TEC.
Synonyms:
Signal-transducing adaptor protein 1 (STAP-1) (BCR downstream-signaling protein 1) (Docking protein BRDG1) (Stem cell adaptor protein 1), STAP1, BRDG1
UniProt Protein Function:
STAP1: an adaptor protein which contains pleckstrin homology (PH) and Src homology 2-like (SRC) domains and a proline-rich region. Induced in activated bone marrow-derived macrophages, and by CpG, LPS, and interferon in myeloid cell lines. Induces pro-inflammatory responses and may contribute to neuronal apoptosis and degeneration. Overexpressed, it interacts with the CSFR, inhibiting its ligand-dependent phosphorylation. Its expression inhibits cellular migration and can increase cytotoxicity against 661W photoreceptor like cells.Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: 4q13.2Cellular Component: cytoplasm; mitochondrion; nucleus; protein complexMolecular Function: phosphotyrosine binding; protein binding; protein kinase binding; SH3/SH2 adaptor activity; transmembrane receptor protein tyrosine kinase adaptor protein activityBiological Process: negative regulation of phosphorylation; positive regulation of B cell receptor signaling pathway; positive regulation of phagocytosis, engulfment; transmembrane receptor protein tyrosine kinase signaling pathway
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene contains a proline-rich region, a pleckstrin homology (PH) domain, and a region in the carboxy terminal half with similarity to the Src Homology 2 (SH2) domain. This protein is a substrate of tyrosine-protein kinase Tec, and its interaction with tyrosine-protein kinase Tec is phosphorylation-dependent. This protein is thought to participate in a positive feedback loop by upregulating the activity of tyrosine-protein kinase Tec. Variants of this gene have been associated with autosomal-dominant hypercholesterolemia (ADH), which is characterized by elevated low-density lipoprotein cholesterol levels and in increased risk of coronary vascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
