STAG2 Antibody (PACO12500)
- SKU:
- PACO12500
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
STAG2 Antibody (PACO12500)
The STAG2 Monoclonal Antibody (PAC012500) is a valuable tool for researchers studying STAG2, a key player in the cohesion complex that regulates chromosome segregation during cell division. This antibody, produced using hybridoma technology, is highly specific to human STAG2 and is validated for use in various applications, including immunofluorescence and immunohistochemistry.STAG2, also known as stromal antigen 2, is essential for maintaining chromosomal stability and proper cell division. Mutations in the STAG2 gene have been implicated in various cancers, making it a promising target for cancer research and drug development.
By targeting STAG2, researchers can better understand its role in tumorigenesis and potentially identify new therapeutic approaches for cancer treatment.Overall, the STAG2 Monoclonal Antibody (PAC012500) is a reliable tool for investigating the function of STAG2 in cellular processes and disease states, with the potential to advance our understanding of cancer biology and facilitate the development of new therapies.
| Antibody Name: | STAG2 Antibody (PACO12500) |
| Antibody SKU: | PACO12500 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human STAG2 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | stromal antigen 2;STAG2;DKFZp686P168;DKFZp781H1753;FLJ25871;SA-2;SA2;bA517O1.1 ; |
| UniProt Protein Function: | STAG2: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Interacts directly with RAD21 in cohesin complex. Cohesin complexes are composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein (STAG1, STAG2 or STAG3). In cohesin complexes, STAG2 is mutually exclusive with STAG1 and STAG3. Belongs to the SCC3 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: Xq25 Cellular Component: actin cytoskeleton; chromatin; chromosome; chromosome, pericentric region; cytosol; intermediate filament cytoskeleton; membrane; nucleolus; nucleoplasm; nucleus; plasma membrane Molecular Function:protein binding Biological Process: negative regulation of DNA endoreduplication; protein sumoylation; sister chromatid cohesion |
| NCBI Summary: | The protein encoded by this gene is a subunit of the cohesin complex, which regulates the separation of sister chromatids during cell division. Targeted inactivation of this gene results in chromatid cohesion defects and aneuploidy, suggesting that genetic disruption of cohesin is a cause of aneuploidy in human cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013] |
| UniProt Code: | Q8N3U4 |
| NCBI GenInfo Identifier: | 73621291 |
| NCBI Gene ID: | 10735 |
| NCBI Accession: | Q8N3U4.3 |
| UniProt Secondary Accession: | Q8N3U4,O00540, Q5JTI6, Q68DE9, Q9H1N8, B1AMT5, D3DTF5 |
| UniProt Related Accession: | Q8N3U4 |
| Molecular Weight: | 145,751 Da |
| NCBI Full Name: | Cohesin subunit SA-2 |
| NCBI Synonym Full Names: | stromal antigen 2 |
| NCBI Official Symbol: | STAG2Â Â |
| NCBI Official Synonym Symbols: | SA2; SA-2; SCC3B; bA517O1.1Â Â |
| NCBI Protein Information: | cohesin subunit SA-2 |
| UniProt Protein Name: | Cohesin subunit SA-2 |
| UniProt Synonym Protein Names: | SCC3 homolog 2; Stromal antigen 2 |
| Protein Family: | Cofilin |
| UniProt Gene Name: | STAG2Â Â |
| UniProt Entry Name: | STAG2_HUMAN |
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