The Stabilin-2 Polyclonal Antibody (CAB10074) is a research tool designed for studying Stabilin-2, a cell surface receptor involved in the clearance of various molecules from the bloodstream. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the Stabilin-2 protein, this antibody enables researchers to detect and analyze Stabilin-2 expression in different cell types, making it an ideal tool for investigations in the fields of immunology and vascular biology.Stabilin-2 plays a crucial role in maintaining vascular homeostasis by regulating the uptake and clearance of extracellular molecules such as lipoproteins, advanced glycation end products, and apoptotic cells.
Dysregulation of Stabilin-2 function has been implicated in various pathological conditions, including atherosclerosis, inflammation, and cancer metastasis. Therefore, studying the expression and activity of Stabilin-2 using this specific antibody can provide valuable insights into the mechanisms underlying these diseases and may contribute to the development of novel therapeutic strategies targeting Stabilin-2.
Product Name:
STAB2 Rabbit Polyclonal Antibody
SKU:
CAB10074
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1550-1850 of human STAB2 (NP_060034.9).
Cell membrane, Cytoplasm, Single-pass type I membrane protein.
Calculated MW:
277kDa
Observed MW:
277kDa
This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 15 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to bind and endocytose ligands such as hyaluronan, low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein has been shown to cycle between the plasma membrane and lysosomes.
Purification Method:
Affinity purification
Gene ID:
55576
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using STAB2 Rabbit pAb (CAB10074) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
