STAB1 Antibody (PACO20609)
- SKU:
- PACO20609
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
STAB1 Antibody (PACO20609)
The STAB1 Polyclonal Antibody (PACO20609) is a valuable tool for research involving STAB1, a key protein involved in immune regulation and inflammation. This antibody, developed against STAB1, is highly specific for human samples and is validated for use in Western blot applications. It binds specifically to STAB1, allowing for the detection and analysis of this protein in various cell types.STAB1, also known as stabilin-1, plays a crucial role in immune response modulation by regulating the clearance of endocytosed molecules and maintaining tissue homeostasis. Its involvement in inflammatory processes makes it a promising target for research in immunology and cancer studies.
Understanding the function of STAB1 is essential for developing potential therapies targeting immune dysregulation and inflammatory conditions.Overall, the STAB1 Polyclonal Antibody is a valuable tool for studying the function and regulation of STAB1 in various biological contexts, providing insights into immune modulation and inflammatory responses. Its specificity and reliability make it an ideal choice for researchers looking to advance our understanding of immune regulation and potential therapeutic targets.
| Antibody Name: | STAB1 Antibody (PACO20609) |
| Antibody SKU: | PACO20609 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human STAB1 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO20609(STAB1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 16 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. |
| Synonyms: | stabilin 1 |
| UniProt Protein Function: | STAB1: Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 3p21.1 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:low-density lipoprotein receptor activity; protein binding; hyaluronic acid binding; low-density lipoprotein binding; protein disulfide oxidoreductase activity; scavenger receptor activity Biological Process: receptor-mediated endocytosis; negative regulation of angiogenesis; cell-cell signaling; defense response to bacterium; cell adhesion; inflammatory response |
| NCBI Summary: | This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 16 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to endocytose ligands such as low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein rapidly cycles between the plasma membrane and early endosomes. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NY15 |
| NCBI GenInfo Identifier: | 296452949 |
| NCBI Gene ID: | 23166 |
| NCBI Accession: | Q9NY15.3 |
| UniProt Secondary Accession: | Q9NY15,Q8IUH0, Q8IUH1, Q93072, A7E297, |
| UniProt Related Accession: | Q9NY15 |
| Molecular Weight: | 87,026 Da |
| NCBI Full Name: | Stabilin-1 |
| NCBI Synonym Full Names: | stabilin 1 |
| NCBI Official Symbol: | STAB1Â Â |
| NCBI Official Synonym Symbols: | FEX1; FEEL-1; FELE-1; STAB-1; CLEVER-1Â Â |
| NCBI Protein Information: | stabilin-1; MS-1 antigen; common lymphatic endothelial and vascular endothelial receptor-1; fasciclin egf-like, laminin-type egf-like, and link domain-containing scavenger receptor-1; fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 1 |
| UniProt Protein Name: | Stabilin-1 |
| UniProt Synonym Protein Names: | Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 1; FEEL-1; MS-1 antigen |
| Protein Family: | Stabilin |
| UniProt Gene Name: | STAB1Â Â |
| UniProt Entry Name: | STAB1_HUMAN |
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