ST8SIA5 Antibody (PACO30158)
- SKU:
- PACO30158
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
ST8SIA5 Antibody (PACO30158)
The ST8SIA5 Polyclonal Antibody (PAC030158) is a valuable tool for researchers studying the ST8SIA5 protein, a key player in the biosynthesis of polysialic acid (PSA) on neural cell adhesion molecule (NCAM). This antibody, produced in rabbits, has high specificity for human samples and has been validated for use in Western blot applications. By binding to the ST8SIA5 protein, this antibody allows for the detection and analysis of ST8SIA5 in various cell types, making it an ideal choice for studies in neuroscience and developmental biology.
ST8SIA5 is essential for regulating cell-cell interactions in the nervous system and is involved in processes such as neural development, plasticity, and regeneration. Dysregulation of ST8SIA5 expression has been implicated in various neurological disorders, making it a promising target for therapeutic interventions. By studying the role of ST8SIA5, researchers can gain insights into the mechanisms underlying neurodevelopmental disorders and potentially identify new treatment strategies.
| Antibody Name: | ST8SIA5 Antibody (PACO30158) |
| Antibody SKU: | PACO30158 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Alpha-2,8-sialyltransferase 8E protein (101-376AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot Positive WB detected in: U87 whole cell lysate All lanes: ST8SIA5 antibody at 3.5µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 44, 48 kDa Observed band size: 44 kDa . |
 | Immunohistochemistry of paraffin-embedded human prostate cancer using PACO30158 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human liver cancer using PACO30158 at dilution of 1:100. |
| Background: | May be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b and GT3 from GD1a, GT1b, GM1b and GD3 respectively. |
| Synonyms: | Alpha-2,8-sialyltransferase 8E (EC 2.4.99.-) (Sialyltransferase 8E) (SIAT8-E) (Sialyltransferase St8Sia V) (ST8SiaV), ST8SIA5, SIAT8E |
| UniProt Protein Function: | ST8SIA5: May be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b and GT3 from GD1a, GT1b, GM1b and GD3 respectively. Belongs to the glycosyltransferase 29 family.Protein type: Membrane protein, integral; Glycan Metabolism - glycosphingolipid biosynthesis - ganglio series; EC 2.4.99.-; TransferaseChromosomal Location of Human Ortholog: 18q21.1Cellular Component: Golgi membrane; integral to Golgi membraneMolecular Function: alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity; sialyltransferase activityBiological Process: glycosphingolipid biosynthetic process; cellular protein metabolic process; dolichol-linked oligosaccharide biosynthetic process; carbohydrate metabolic process; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a type II membrane protein that may be present in the Golgi apparatus. The encoded protein, which is a member of glycosyltransferase family 29, may be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b, and GT3 from GD1a, GT1b, GM1b, and GD3, respectively. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O15466 |
| NCBI GenInfo Identifier: | 28373101 |
| NCBI Gene ID: | 29906 |
| NCBI Accession: | NP_037437.2 |
| UniProt Secondary Accession: | O15466,Q6IAW7 |
| UniProt Related Accession: | O15466 |
| Molecular Weight: | 43,895 Da |
| NCBI Full Name: | alpha-2,8-sialyltransferase 8E |
| NCBI Synonym Full Names: | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 |
| NCBI Official Symbol: | ST8SIA5Â Â |
| NCBI Official Synonym Symbols: | SIAT8E; ST8SiaVÂ Â |
| NCBI Protein Information: | alpha-2,8-sialyltransferase 8E; SIAT8-E; sialytransferase St8Sia V; sialyltransferase St8Sia V; sialyltransferase 8E (alpha-2, 8-polysialytransferase) |
| UniProt Protein Name: | Alpha-2,8-sialyltransferase 8E |
| UniProt Synonym Protein Names: | Sialyltransferase 8E; SIAT8-E; Sialyltransferase St8Sia V; ST8SiaV |
| Protein Family: | Alpha-2,8-sialyltransferase |
| UniProt Gene Name: | ST8SIA5Â Â |
| UniProt Entry Name: | SIA8E_HUMAN |
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