The ST8SIA4 Polyclonal Antibody (CAB6754) is a crucial tool for researchers studying ST8SIA4, a key enzyme involved in the biosynthesis of polysialic acid (PSA) chains on neural cell adhesion molecules (NCAMs). This antibody, produced in rabbits, exhibits high specificity and reactivity towards human samples, making it a reliable choice for Western blot applications.ST8SIA4 is essential for neural development and plasticity, playing a critical role in processes such as neuronal migration, axon guidance, and synaptic plasticity. Dysregulation of ST8SIA4 expression has been associated with neurological disorders, making it a promising target for therapeutic interventions.
By facilitating the detection and analysis of ST8SIA4, this antibody enables researchers to further explore its function in neurobiology and neurodevelopmental disorders. With its proven efficacy in detecting ST8SIA4 in various cell types, the ST8SIA4 Polyclonal Antibody (CAB6754) is a valuable tool for investigations into neural development, synaptic plasticity, and neurological diseases. Researchers can rely on this antibody to advance their understanding of ST8SIA4 and its potential implications in health and disease.
Product Name:
ST8SIA4 Rabbit Polyclonal Antibody
SKU:
CAB6754
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-168 of human ST8SIA4 (NP_778222.1).
Golgi apparatus membrane, Single-pass type II membrane protein.
Calculated MW:
41kDa
Observed MW:
41kDa
The protein encoded by this gene catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). The encoded protein, which is a member of glycosyltransferase family 29, is a type II membrane protein that may be present in the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
7903
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ST8SIA4 Antibody (CAB6754) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 90s.
