The ST8SIA1 Polyclonal Antibody (CAB9648) is a valuable tool for researchers studying ST8SIA1, an enzyme involved in the biosynthesis of polysialic acids. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blotting applications. By targeting the ST8SIA1 enzyme, this antibody allows for the detection and analysis of ST8SIA1 expression in a variety of cell types, making it ideal for research in neurobiology, developmental biology, and cancer biology.
ST8SIA1 plays a crucial role in neural development and plasticity, making it an important target for studying neurological disorders and brain function. Dysregulation of ST8SIA1 expression has been linked to conditions such as schizophrenia, Alzheimer's disease, and various forms of cancer. By understanding the function and regulation of ST8SIA1, researchers can gain valuable insights into the underlying mechanisms of these diseases and potentially develop targeted therapeutic interventions.
Product Name:
ST8SIA1 Rabbit Polyclonal Antibody
SKU:
CAB9648
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 49-270 of human ST8SIA1 (NP_003025.1).
Golgi apparatus membrane, Single-pass type II membrane protein.
Calculated MW:
41kDa
Observed MW:
41kDa
Gangliosides are membrane-bound glycosphingolipids containing sialic acid. Ganglioside GD3 is known to be important for cell adhesion and growth of cultured malignant cells. The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to GM3 to produce gangliosides GD3 and GT3. The encoded protein may be found in the Golgi apparatus and is a member of glycosyltransferase family 29. Alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
6489
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse kidney, using ST8SIA1 Rabbit pAb (CAB9648) at 1:8000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
