The ST6GALNAC4 Polyclonal Antibody (CAB12880) is a valuable tool for researchers studying ST6GALNAC4, a glycosyltransferase enzyme involved in glycosylation processes. This antibody, produced in rabbits, is highly specific to human samples, making it an ideal choice for experiments involving ST6GALNAC4 protein detection in Western blot assays.ST6GALNAC4 plays a crucial role in the glycosylation of proteins, which is essential for various cellular processes including cell adhesion, signaling, and immune response regulation. Dysregulation of glycosylation pathways, including those involving ST6GALNAC4, has been implicated in cancer, autoimmune diseases, and neurodegenerative disorders.
By using the ST6GALNAC4 Polyclonal Antibody, researchers can gain valuable insights into the role of ST6GALNAC4 in normal cellular function and disease pathology. This antibody is a valuable tool for studies in glycobiology, cancer biology, and immunology, providing researchers with a powerful tool to further their understanding of glycosylation processes and their impact on human health.
Product Name:
ST6GALNAC4 Rabbit Polyclonal Antibody
SKU:
CAB12880
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 120-210 of human ST6GALNAC4 (NP_778204.1).
Golgi apparatus membrane, Single-pass type II membrane protein.
Calculated MW:
34kDa
Observed MW:
34kDa
The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein prefers glycoproteins rather than glycolipids as substrates and shows restricted substrate specificity, utilizing only the trisaccharide sequence Neu5Ac-alpha-2,3-Gal-beta-1,3-GalNAc. In addition, it is involved in the synthesis of ganglioside GD1A from GM1B. The encoded protein is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29. Transcript variants encoding different isoforms have been found for this gene. Readthrough transcripts exist for this gene and the downstream ST6GALNAC6 gene.
Purification Method:
Affinity purification
Gene ID:
27090
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ST6GALNAC4 Rabbit pAb (CAB12880) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
