null

ST6GALNAC3 Antibody (PACO38574)

SKU:
PACO38574
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$431

Description

system_update_altDatasheetsystem_update_altMSDS

ST6GALNAC3 Antibody (PACO38574)

The ST6GALNAC3 Polyclonal Antibody (PACO38574) is a valuable tool for researchers studying the ST6GALNAC3 protein, a key enzyme involved in glycosylation processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the ST6GALNAC3 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential component for studies in glycobiology and cancer research.ST6GALNAC3 functions as a glycosyltransferase responsible for transferring sialic acids to glycoproteins, impacting crucial cellular processes such as cell adhesion, migration, and signaling.

Dysregulation of ST6GALNAC3 has been implicated in various diseases, including cancer and inflammatory conditions, highlighting its potential as a therapeutic target. By understanding the role of ST6GALNAC3 in glycosylation pathways, researchers can gain insights into disease mechanisms and develop novel treatments targeting aberrant glycosylation patterns.

Antibody Name:ST6GALNAC3 Antibody (PACO38574)
Antibody SKU:PACO38574
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Human
Immunogen:Recombinant Human Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 protein (40-305AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. ST6GalNAcIII prefers glycolipids to glycoproteins.
Synonyms:Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 (EC 2.4.99.-) (GalNAc alpha-2,6-sialyltransferase III) (ST6GalNAc III) (ST6GalNAcIII) (STY) (Sialyltransferase 7C) (SIAT7-C), ST6GALNAC3, SIAT7C
UniProt Protein Function:ST6GALNAC3: Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. ST6GalNAcIII prefers glycolipids to glycoproteins. Belongs to the glycosyltransferase 29 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Transferase; Glycan Metabolism - glycosphingolipid biosynthesis - ganglio series; Membrane protein, integral; EC 2.4.99.-Chromosomal Location of Human Ortholog: 1p31.1Cellular Component: Golgi membrane; integral to membraneMolecular Function: sialyltransferase activityBiological Process: cellular protein metabolic process; glycoprotein metabolic process; dolichol-linked oligosaccharide biosynthetic process; glycosphingolipid metabolic process; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification; glycosylceramide metabolic process
UniProt Protein Details:
NCBI Summary:ST6GALNAC3 belongs to a family of sialyltransferases that transfer sialic acids from CMP-sialic acid to terminal positions of carbohydrate groups in glycoproteins and glycolipids (Lee et al., 1999 [PubMed 10207017]).[supplied by OMIM, Mar 2008]
UniProt Code:Q8NDV1
NCBI GenInfo Identifier:229892275
NCBI Gene ID:256435
NCBI Accession:NP_001153483.1
UniProt Secondary Accession:Q8NDV1,Q6PCE0, Q6UX29, Q8N259
UniProt Related Accession:Q8NDV1
Molecular Weight:24,022 Da
NCBI Full Name:alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform 2
NCBI Synonym Full Names:ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
NCBI Official Symbol:ST6GALNAC3  
NCBI Official Synonym Symbols:STY; SIAT7C; PRO7177; ST6GALNACIII  
NCBI Protein Information:alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; SIAT7-C; ST6GALNAC III; sialyltransferase 7C; GalNAc alpha-2,6-sialyltransferase III; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase III; ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltran; sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) C
UniProt Protein Name:Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
UniProt Synonym Protein Names:GalNAc alpha-2,6-sialyltransferase III; ST6GalNAc III; ST6GalNAcIII; STY; Sialyltransferase 7C; SIAT7-C
Protein Family:Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase
UniProt Gene Name:ST6GALNAC3  
UniProt Entry Name:SIA7C_HUMAN

Related Products