The ST6GALNAC1 Polyclonal Antibody (PACO12492) is a valuable tool for researchers studying ST6GALNAC1, an enzyme involved in the biosynthesis of sialyl-T antigen. This antibody, produced using rabbits, shows high reactivity with human samples and is suitable for Western blot applications. By binding to the ST6GALNAC1 protein, this antibody enables the detection and analysis of ST6GALNAC1 expression in various cell types, making it an excellent choice for investigations in glycobiology and cancer research.ST6GALNAC1, a key player in sialylation pathways, is crucial for the modification of glycoproteins and glycolipids.
Dysregulation of ST6GALNAC1 has been linked to cancer progression, metastasis, and immune evasion, highlighting its importance in tumor biology. Research on ST6GALNAC1 may provide insights into potential therapeutic targets for cancer treatment and strategies for cancer diagnosis.Overall, the ST6GALNAC1 Polyclonal Antibody (PACO12492) is a valuable tool for researchers interested in exploring the role of ST6GALNAC1 in cancer biology and glycosylation processes. Its specificity and sensitivity make it a reliable option for studies aiming to elucidate the functions and mechanisms of ST6GALNAC1 in health and disease.
ST6GALNAC1: Belongs to the glycosyltransferase 29 familyProtein type: Transferase; Membrane protein, integral; EC 2.4.99.3; Glycan Metabolism - O-glycan biosynthesisChromosomal Location of Human Ortholog: 17q25.1Cellular Component: Golgi membraneMolecular Function: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activityBiological Process: ganglioside biosynthetic process; oligosaccharide metabolic process; protein amino acid N-linked glycosylation via asparagine
UniProt Protein Details:
NCBI Summary:
Glycosylation of proteins affects cell-cell interaction, interactions with the matrix, and the functions of intracellular molecules. ST6GALNAC1 transfers a sialic acid, N-acetylneuraminic acid (NeuAc), in an alpha-2,6 linkage to O-linked GalNAc residues. The cancer-associated sialyl-Tn (sTn) antigen is formed by ST6GALNAC1-catalyzed sialylation of GalNAc residues on mucins (Ikehara et al., 1999 [PubMed 10536037]; Sewell et al., 2006 [PubMed 16319059]).[supplied by OMIM, Mar 2008]
