The ST3GAL3 Polyclonal Antibody (CAB6753) is a valuable tool for researchers studying ST3GAL3, an enzyme responsible for the addition of sialic acids to glycoproteins and glycolipids. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the ST3GAL3 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an ideal choice for studies in glycobiology and cancer research.
ST3GAL3 plays a crucial role in the modification of cell surface molecules, impacting various cellular processes such as cell adhesion, signaling, and immune recognition. Dysregulation of ST3GAL3 has been linked to tumorigenesis, metastasis, and immune evasion in cancer, highlighting its potential as a therapeutic target. Investigating the function and regulation of ST3GAL3 is essential for understanding its implications in disease pathology and developing targeted interventions for cancer and other related conditions.
Product Name:
ST3GAL3 Rabbit Polyclonal Antibody
SKU:
CAB6753
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 30-375 of human ST3GAL3 (NP_006270.1).
Golgi apparatus, Golgi stack membrane, Secreted, Single-pass type II membrane protein.
Calculated MW:
42kDa
Observed MW:
42kDa
The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29. Mutations in this gene have been associated with a form of autosomal recessive nonsymdromic cognitive disability as well as infantile epileptic encephalopathy. Multiple transcript variants encoding several different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
6487
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using ST3GAL3 Rabbit pAb (CAB6753) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
