The ST18 Polyclonal Antibody (PAC017158) is a valuable tool for researchers studying ST18, a protein involved in immune regulation and cell signaling. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the ST18 protein, this antibody enables the detection and analysis of ST18 in various cell types, making it ideal for investigations in immunology and cancer research.ST18, also known as a regulator of cell growth and differentiation, plays a crucial role in various cellular processes, including apoptosis and cell cycle regulation.
Its involvement in immune responses and inflammation suggests its potential as a therapeutic target in diseases such as cancer, autoimmune disorders, and inflammatory conditions. Understanding the function of ST18 is essential for developing new treatment strategies that modulate immune responses and promote tissue homeostasis.
Antibody Name:
ST18 Antibody (PACO17158)
Antibody SKU:
PACO17158
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Fusion protein of human ST18
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17158(ST18 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
Background:
ST18 (suppression of tumorigenicity 18), also known as ZNF387 ((zinc finger protein 387), is a 1,047 amino acid, nuclear protein that is expressed at low levels in heart, liver, kidney, skeletal muscle, pancreas, testis, ovary and prostate. Containing six C2HC-type zinc fingers and an SMC domain, ST18 is a repressor protein that binds to DNA sequences containing a specific bipartite element. ST18 is considered a transcription factor that represses basal transcription activity from target promoters and Inhibits colony formation in cultured breast cancer cells.
Synonyms:
suppression of tumorigenicity 18, zinc finger
UniProt Protein Function:
ST18: Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of the sequence 5'-AAAGTTT-3' separated by 2-9 nucleotides. Represses basal transcription activity from target promoters. Inhibits colony formation in cultured breast cancer cells.Chromosomal Location of Human Ortholog: 8q11.23Cellular Component: nucleusMolecular Function: DNA binding; zinc ion binding; transcription factor activityBiological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent
