Hsc70-interacting protein (HIP) Rabbit Polyclonal Antibody (CAB8454)
The ST13 Polyclonal Antibody (CAB8454) is a powerful tool for researchers studying the ST13 protein, a chaperone involved in protein folding and intracellular trafficking. This antibody, generated in rabbits, exhibits high specificity and reactivity with human samples, making it suitable for various applications including Western blot analysis.ST13, also known as HSPC155 or CHIP, plays a crucial role in maintaining protein quality control and preventing misfolding and aggregation. Dysregulation of ST13 has been linked to diseases such as cancer, neurodegenerative disorders, and cardiovascular diseases, making it an important target for therapeutic interventions.
By using the ST13 Polyclonal Antibody, researchers can investigate the expression and function of ST13 in different cell types and tissues, providing valuable insights into its role in disease development and progression. This antibody is a valuable tool for studies in molecular biology, cell biology, and drug discovery related to protein folding and quality control mechanisms.
Product Name:
Hsc70-interacting protein (HIP) Rabbit Polyclonal Antibody
SKU:
CAB8454
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-369 of human Hsc70-interacting protein (HIP) (NP_003923.2).
The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that it is a candidate tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
6767
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Hsc70-interacting protein (HIP) antibody (CAB8454) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
