SSX2IP Antibody (PACO56270)
- SKU:
- PACO56270
- Product Type:
- Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
SSX2IP Antibody (PACO56270)
The SSX2IP Polyclonal Antibody (PAC056270) is specifically designed for research involving SSX2IP, a protein involved in spindle organization and cell division. The antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in various applications, including Western blot and immunofluorescence.SSX2IP plays a critical role in ensuring the proper alignment and segregation of chromosomes during cell division, making it a key player in maintaining genomic stability. Dysregulation of SSX2IP has been linked to chromosomal instability and cancer development, making it a promising target for cancer research and drug development.
The SSX2IP Polyclonal Antibody enables the detection and analysis of SSX2IP protein expression in different cell types, providing valuable insights into its role in cellular processes. Its versatility and specificity make it an essential tool for researchers studying cell division, chromosome segregation, and cancer biology. By understanding the function and regulation of SSX2IP, researchers can gain valuable insights into the mechanisms underlying cancer development and potentially identify novel therapeutic targets for cancer treatment.
| Antibody Name: | SSX2IP Antibody (PACO56270) |
| Antibody SKU: | PACO56270 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human, Rat |
| Immunogen: | Recombinant Human Afadin- and alpha-actinin-binding protein (485-614AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Hela whole cell lysate, Rat liver tissue. All lanes: SSX2IP antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 72, 66, 69 kDa. Observed band size: 72 kDa. |
 | IHC image of PACO56270 diluted at 1:100 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
 | IHC image of PACO56270 diluted at 1:100 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (By similarity). Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (By similarity). Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome. Involved in ciliogenesis. It is required for targeted recruitment of the BBSome, CEP290, RAB8, and SSTR3 to the cilia. |
| Synonyms: | Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain-interacting protein) (SSX2-interacting protein), SSX2IP, KIAA0923 |
| UniProt Protein Function: | SSX2IP: Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E- cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Cell adhesionChromosomal Location of Human Ortholog: 1p22.3Cellular Component: protein complex; cell-cell adherens junction; leading edge; nucleusMolecular Function: protein domain specific binding; protein bindingBiological Process: regulation of Rac protein signal transduction; centrosome organization and biogenesis; cilium biogenesis; cell adhesion |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a protein that binds the cancer-testis antigen Synovial Sarcoma X breakpoint 2 protein. The encoded protein may regulate the activity of Synovial Sarcoma X breakpoint 2 protein in malignant cells. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Oct 2009] |
| UniProt Code: | Q9Y2D8 |
| NCBI GenInfo Identifier: | 261878552 |
| NCBI Gene ID: | 117178 |
| NCBI Accession: | NP_001159889.1 |
| UniProt Secondary Accession: | Q9Y2D8,Q6P2P8, Q6ULS1, Q7L168, Q9UIX0, A8K8W0, B4DFE3 D3DT13, J3KR02 |
| UniProt Related Accession: | Q9Y2D8 |
| Molecular Weight: | 68,274 Da |
| NCBI Full Name: | afadin- and alpha-actinin-binding protein isoform 1 |
| NCBI Synonym Full Names: | synovial sarcoma, X breakpoint 2 interacting protein |
| NCBI Official Symbol: | SSX2IPÂ Â |
| NCBI Official Synonym Symbols: | ADIPÂ Â |
| NCBI Protein Information: | afadin- and alpha-actinin-binding protein; SSX2-interacting protein; afadin DIL domain-interacting protein |
| UniProt Protein Name: | Afadin- and alpha-actinin-binding protein |
| UniProt Synonym Protein Names: | Afadin DIL domain-interacting protein; SSX2-interacting protein |
| Protein Family: | Afadin- and alpha-actinin-binding protein |
| UniProt Gene Name: | SSX2IPÂ Â |
| UniProt Entry Name: | ADIP_HUMAN |
| Antibodies |
| SSX2IP Antibody (PACO12483) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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