The SSX2 Polyclonal Antibody (CAB13548) is specifically designed for research involving the SSX2 protein, a member of the cancer/testis antigen family that is predominantly expressed in the testis and various types of cancer cells. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in applications such as Western blotting.SSX2 is known to play a role in tumorigenesis and has been implicated in the development and progression of various cancers, making it a promising target for cancer research. By binding to the SSX2 protein, this antibody enables detection and analysis in a variety of cell types, making it an invaluable tool for studies in oncology and molecular biology.
Understanding the function and expression of SSX2 is essential for advancing our knowledge of cancer biology and developing targeted therapies for cancer treatment. The SSX2 Polyclonal Antibody offers researchers a reliable and effective tool for investigating the role of SSX2 in cancer progression and exploring its potential as a therapeutic target in the fight against cancer.
Product Name:
SSX2 Rabbit Polyclonal Antibody
SKU:
CAB13548
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-188 of human SSX2 (NP_783629.1).
The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. This gene, and also the SSX1 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. This gene also has an identical duplicate, GeneID: 727837, located about 45 kb downstream in the opposite orientation on chromosome X.
Purification Method:
Affinity purification
Gene ID:
6757
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunofluorescence analysis of HeLa cells using SSX2 antibody (CAB13548). Blue: DAPI for nuclear staining.
