The SSX1 Monoclonal Antibody (PAC017152) is a valuable tool for researchers interested in studying the SSX1 protein, which is involved in various cancer types. This antibody has been specifically designed for use in Western blot and immunohistochemical applications, providing reliable and reproducible results.SSX1 is a member of the cancer-testis antigen family and is known to play a role in the development and progression of cancers such as melanoma and sarcoma. By targeting the SSX1 protein, researchers can gain insights into the molecular mechanisms underlying cancer growth and metastasis.
The SSX1 Monoclonal Antibody has been rigorously validated for use with human samples, ensuring high specificity and sensitivity. Its ability to detect SSX1 in various cell types makes it a valuable asset for cancer research and drug development efforts aimed at targeting SSX1 for therapeutic purposes.Overall, the SSX1 Monoclonal Antibody (PAC017152) is a reliable tool for investigating the role of the SSX1 protein in cancer biology, offering researchers a powerful means to advance our understanding of this critical target for potential therapeutic interventions.
Antibody Name:
SSX1 Antibody (PACO17152)
Antibody SKU:
PACO17152
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:5000, WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
Fusion protein of human SSX1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: K562 cells, Primary antibody: PACO17152(SSX1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute.
Background:
The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy.
Synonyms:
synovial sarcoma, X breakpoint 1
UniProt Protein Function:
SSX1: Could act as a modulator of transcription. A chromosomal aberration involving SSX1 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency). Belongs to the SSX family.Protein type: Oncoprotein; Cancer Testis Antigen (CTA)Chromosomal Location of Human Ortholog: Xp11.23Molecular Function: protein binding; transcription corepressor activityDisease: Sarcoma, Synovial
UniProt Protein Details:
NCBI Summary:
The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. This gene, and also the SSX2 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Jul 2013]
