Anti-SSTR4 Antibody (CAB6988)
- SKU:
- CAB6988
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Anti-SSTR4 Antibody (CAB6988)
The SSTr4 Polyclonal Antibody (CAB6988) is a valuable tool for researchers studying the SSTr4 receptor, a G-protein coupled receptor involved in the regulation of metabolism and energy balance. This antibody, created against SSTr4 protein in rabbits, demonstrates high reactivity with human samples and is validated for use in various applications, including Western blot and immunohistochemistry.SSTr4, also known as somatostatin receptor 4, plays a pivotal role in modulating hormone secretion, neurotransmission, and cell proliferation.
Its involvement in various physiological processes makes it a promising target for investigating metabolic disorders, neuroendocrine tumors, and neurodegenerative diseases. The SSTr4 Polyclonal Antibody enables researchers to detect and analyze SSTr4 expression in different tissues and cell types, providing valuable insights into its function and potential therapeutic applications.
| Antibody Name: | Anti-SSTR4 Antibody |
| Antibody SKU: | CAB6988 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 314-388 of human SSTR4 (NP_001043.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HL-60, BT-474, HepG2, Mouse brain, Rat brain, Rat lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 314-388 of human SSTR4 (NP_001043.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LSDN FRRF FQRV LCLR CCLL EGAG GAEE EPLD YYAT ALKS KGGA GCMC PPLP CQQE ALQP EPGR KRIP LTRT TTF |
| Gene ID: | 6754 |
| Uniprot: | P31391 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 42kDa |
| Observed MW: | 39kDa |
| Synonyms: | SSTR4, SS-4-R, SS4-R, SS4R |
| Background: | Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung. |
| UniProt Protein Function: | SSTR4: Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells. Belongs to the G-protein coupled receptor 1 family. |
| UniProt Protein Details: | Protein type:GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 20p11.2 Cellular Component: cytoplasm; integral to plasma membrane; neuron projection; plasma membrane Molecular Function:neuropeptide binding; somatostatin receptor activity Biological Process: arachidonic acid metabolic process; cell migration; forebrain development; G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to cyclic nucleotide second messenger; negative regulation of cAMP metabolic process; negative regulation of cell proliferation; positive regulation of MAPKKK cascade |
| NCBI Summary: | Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P31391 |
| NCBI GenInfo Identifier: | 206729897 |
| NCBI Gene ID: | 6754 |
| NCBI Accession: | P31391.2 |
| UniProt Secondary Accession: | P31391,Q17RM1, Q17RM3, Q9UIY1, |
| UniProt Related Accession: | P31391 |
| Molecular Weight: | 42,003 Da |
| NCBI Full Name: | Somatostatin receptor type 4 |
| NCBI Synonym Full Names: | somatostatin receptor 4 |
| NCBI Official Symbol: | SSTR4Â Â |
| NCBI Official Synonym Symbols: | SS4R; SS4-R; SS-4-RÂ Â |
| NCBI Protein Information: | somatostatin receptor type 4 |
| UniProt Protein Name: | Somatostatin receptor type 4 |
| Protein Family: | Somatostatin receptor |
| UniProt Gene Name: | SSTR4Â Â |
| UniProt Entry Name: | SSR4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SSTR4 antibody (CAB6988) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 300s. |
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