SSRP1 Rabbit Polyclonal Antibody (CAB6413)
- SKU:
- CAB6413
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | SSRP1 Rabbit Polyclonal Antibody |
SKU: | CAB6413 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human SSRP1 (NP_003137.1). |
Sequence: | MAET LEFN DVYQ EVKG SMND GRLR LSRQ GIIF KNSK TGKV DNIQ AGEL TEGI WRRV ALGH GLKL LTKN GHVY KYDG FRES EFEK LSDF FKTH YRLE LMEK DLCV KGWN WGTV KFGG QLLS FDIG DQPV FEIP LSNV SQCT TGKN EVTL EFHQ NDDA EVSL MEVR FYVP PTQE DGVD PVEA FAQN VLSK ADVI QATG DAIC IFRE LQCL TPRG RYDI RIYP TFLH LHGK TFDY KIPY TTVL RLFL LPHK DQRQ MFFV ISLD PPIK QGQT RYHF LILL FSKD EDIS LTLN MNEE EVEK RFEG |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:100 - 1:500 IHC-P,1:50 - 1:200 IF/ICC,1:10 - 1:100 |
Synonyms: | FACT; T160; FACT80; SSRP1 |
Positive Sample: | Mouse brain |
Conjugate: | Unconjugated |
Cellular Localization: | Chromosome, Nucleus, nucleolus. |
Calculated MW: | 81kDa |
Observed MW: | 90kDa |
The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known.
Purification Method: | Affinity purification |
Gene ID: | 6749 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |