The SSRP1 Polyclonal Antibody (CAB6413) is a critical tool for researchers studying the SSRP1 protein, which is involved in chromatin remodeling and DNA repair processes. This antibody, produced in rabbits, is highly specific and reactive for human samples, making it ideal for use in Western blot applications. By binding to the SSRP1 protein, this antibody enables accurate detection and analysis in a variety of cell types, offering valuable insights for studies in genetics, cancer biology, and epigenetics.SSRP1, also known as structure-specific recognition protein 1, plays a crucial role in maintaining genome stability and regulating gene expression.
Dysregulation of SSRP1 has been implicated in various diseases, including cancer and developmental disorders. The ability to accurately measure SSRP1 levels in cells and tissues using this antibody is essential for understanding its function and potential role in disease progression. Researchers can use this antibody to explore the molecular mechanisms underlying SSRP1 activity and develop targeted therapies for conditions associated with SSRP1 dysfunction.
Product Name:
SSRP1 Rabbit Polyclonal Antibody
SKU:
CAB6413
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human SSRP1 (NP_003137.1).
The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known.
Purification Method:
Affinity purification
Gene ID:
6749
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse brain, using SSRP1 Rabbit pAb (CAB6413) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
