The SSRP1 Polyclonal Antibody (CAB13636) is a valuable tool for researchers studying the SSRP1 protein, which plays a key role in chromatin remodeling and gene expression regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blotting applications. By binding specifically to SSRP1, this antibody enables accurate detection and analysis of the protein in various cell types, making it an essential component in studies related to epigenetics, cancer, and gene regulation.SSRP1, also known as Structure-Specific Recognition Protein 1, is a critical component of the FACT complex involved in DNA transcription and repair.
Its function in chromatin organization and gene expression makes it a crucial target for research into diseases such as cancer, where aberrant gene regulation plays a significant role. Understanding the role of SSRP1 in these processes is vital for developing targeted therapies and diagnostic tools for a range of conditions.Overall, the SSRP1 Polyclonal Antibody provides researchers with a reliable tool for investigating the functions and pathways regulated by SSRP1, offering valuable insights into the molecular mechanisms underlying various diseases and potential therapeutic strategies.
Product Name:
SSRP1 Rabbit Polyclonal Antibody
SKU:
CAB13636
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human SSRP1 (NP_003137.1).
The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known.
Purification Method:
Affinity purification
Gene ID:
6749
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using SSRP1 Rabbit pAb (CAB13636) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
