The SSH3 Polyclonal Antibody (PACO01544) is a valuable tool for researchers studying the SSH3 protein, a key player in cell signaling processes. This antibody, generated in rabbits, is highly specific for SSH3 and has been validated for use in various research applications, including Western blotting. By binding to the SSH3 protein, this antibody enables precise detection and analysis in different cell types, making it ideal for studies in cell biology and signal transduction pathways.SSH3, also known as Slingshot Homolog 3, is involved in actin cytoskeleton dynamics and cell migration, making it a crucial regulator of cellular processes like cell shape changes and motility.
Understanding the functions of SSH3 is essential for unraveling its roles in development, cancer progression, and other physiological processes. The SSH3 Polyclonal Antibody provides researchers with a reliable tool to investigate the mechanisms underlying SSH3-mediated signaling pathways and its potential implications in various diseases and conditions.
Antibody Name:
SSH3 Antibody
Antibody SKU:
PACO01544
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the Internal region of human SSH3.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
SSH3; SSH3L; Protein phosphatase Slingshot homolog 3; SSH-like protein 3; SSH-3L; hSSH-3L
UniProt Protein Function:
SSH3: a protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Does not bind to, or colocalize with, filamentous actin. Five alternatively spliced isoforms have been described.Protein type: Cytoskeletal; EC 3.1.3.16; Protein phosphatase, dual-specificity; Phosphatase; Motility/polarity/chemotaxis; EC 3.1.3.48; Protein phosphatase, Ser/Thr (non-receptor)Chromosomal Location of Human Ortholog: 11q13.2Cellular Component: cytoplasmMolecular Function: actin bindingBiological Process: regulation of actin polymerization and/or depolymerization; regulation of axonogenesis
UniProt Protein Details:
NCBI Summary:
The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002 [PubMed 11832213]).[supplied by OMIM, Mar 2008]
