UniProt Protein Function: | SSH1: a dual-specificity phosphatase of the Slingshot family involved in actin reorganization. Its calcineurin-dependent activation dephosphorylates cofilin. Plays a role in later stages of mitosis by dephosphorylating and activating cofilin.Protein type: EC 3.1.3.16; Protein phosphatase, dual-specificity; EC 3.1.3.48Chromosomal Location of Human Ortholog: 12q24.11Cellular Component: cytoplasm; nucleoplasm; plasma membraneMolecular Function: actin binding; phosphoprotein phosphatase activity; protein bindingBiological Process: actin cytoskeleton organization and biogenesis; cell morphogenesis; protein amino acid dephosphorylation; regulation of actin polymerization and/or depolymerization; regulation of axonogenesis; regulation of cellular protein metabolic process |
UniProt Protein Details: | |
NCBI Summary: | The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] |
UniProt Code: | Q8WYL5 |
NCBI GenInfo Identifier: | 82582267 |
NCBI Gene ID: | 54434 |
NCBI Accession: | Q8WYL5.2 |
UniProt Secondary Accession: | Q8WYL5,Q6P6C0, Q8N9A7, Q8WYL3, Q8WYL4, Q9P2P8 |
UniProt Related Accession: | Q8WYL5 |
Molecular Weight: | 78,978 Da |
NCBI Full Name: | Protein phosphatase Slingshot homolog 1 |
NCBI Synonym Full Names: | slingshot protein phosphatase 1 |
NCBI Official Symbol: | SSH1Â Â |
NCBI Official Synonym Symbols: | SSH1LÂ Â |
NCBI Protein Information: | protein phosphatase Slingshot homolog 1 |
UniProt Protein Name: | Protein phosphatase Slingshot homolog 1 |
UniProt Synonym Protein Names: | SSH-like protein 1; SSH-1L; hSSH-1L |
Protein Family: | Sec sixty-one protein |
UniProt Gene Name: | SSH1Â Â |
UniProt Entry Name: | SSH1_HUMAN |