The Lupus LA Protein Polyclonal Antibody (CAB0630) is a valuable tool for researchers studying lupus, an autoimmune disease characterized by inflammation and tissue damage. This antibody, generated in rabbits, is highly specific for the Lupus LA protein and has been validated for use in Western blot applications. By targeting the Lupus LA protein, this antibody allows for the detection and analysis of this important biomarker in various cell types.The Lupus LA protein, also known as La/SSB, is an autoantigen that plays a key role in the pathogenesis of lupus, making it a crucial target for research into this complex disease. By understanding the activity of Lupus LA, researchers can gain insights into the mechanisms underlying lupus development and progression.
This antibody is a valuable tool for studying the involvement of Lupus LA in lupus and other autoimmune disorders, as well as for exploring potential therapeutic interventions targeting this protein.Overall, the Lupus LA Protein Polyclonal Antibody (CAB0630) is a reliable reagent for researchers interested in investigating the role of the Lupus LA protein in autoimmune diseases like lupus, as well as for those studying the molecular mechanisms involved in autoimmunity. Its high specificity and sensitivity make it an ideal choice for Western blot experiments aimed at elucidating the function of Lupus LA in immune dysregulation.
Product Name:
SSB Rabbit Polyclonal Antibody
SKU:
CAB0630
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 166-408 of human SSB (NP_003133.1).
WB,1:500 - 1:1000 IHC-P,1:100 - 1:500 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Synonyms:
La; LARP3; La/SSB; SSB
Positive Sample:
Jurkat,LO2,HepG2,293T
Conjugate:
Unconjugated
Cellular Localization:
Nucleus.
Calculated MW:
47kDa
Observed MW:
47kDa
The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein.
Purification Method:
Affinity purification
Gene ID:
6741
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using SSB Rabbit pAb (CAB0630) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
