SRY Transcription Factor Activity Assay

SKU:

TFAB00127

Product Type:

ELISA Kit

ELISA Type:

Transcription Factor Assay

Analytes:

SRY

Reactivity:

Human

Mouse

Description

Description

Datasheet

SRY Transcription Factor Activity Assay

The SRY Transcription Factor Activity Assay offered by Assay Genie is a cutting-edge kit designed for the accurate measurement of SRY transcription factor activity in various biological samples. This assay kit boasts high sensitivity and specificity, ensuring precise and reliable results for your research needs.The SRY transcription factor is a key regulator of sex determination and development, making it a critical protein in the field of reproductive biology and genetics. Dysregulation of SRY activity can lead to disorders of sexual development and infertility, highlighting the importance of studying its function in various biological processes.

Whether you are investigating the mechanisms of sex determination, studying developmental biology, or exploring potential therapeutic targets for reproductive disorders, the SRY Transcription Factor Activity Assay kit from Assay Genie provides a valuable tool for your research endeavors. Unlock the secrets of SRY transcription factor activity with this innovative assay kit and take your research to the next level.

UniProt Protein Function:	SRY: Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. Defects in SRY are the cause of 46,XY sex reversal type 1 (SRXY1). A condition characterized by male-to-female sex reversal in the presence of a normal 46,XY karyotype. Patients manifest rapid and early degeneration of their gonads, which are present in the adult as 'streak gonads', consisting mainly of fibrous tissue and variable amounts of ovarian stroma. As a result these patients do not develop secondary sexual characteristics at puberty. The external genitalia in these subjects are completely female, and Muellerian structures are normal. A 45,X chromosomal aberration involving SRY is found in Turner syndrome, a disease characterized by gonadal dysgenesis with short stature, streak gonads, variable abnormalities such as webbing of the neck, cubitus valgus, cardiac defects, low posterior hair line. The phenotype is female. Defects in SRY are the cause of 46,XX sex reversal type 1 (SRXX1). A condition in which male gonads develop in a genetic female (female to male sex reversal). Belongs to the SRY family.
UniProt Protein Details:	Protein type:Nuclear receptor co-regulator; DNA-binding Chromosomal Location of Human Ortholog: Yp11.3 Cellular Component: nucleoplasm; nucleus Molecular Function:DNA binding; RNA polymerase II transcription factor activity, enhancer binding; transcription factor binding Biological Process: positive regulation of transcription, DNA-dependent Disease: 46,xx Sex Reversal 1; 46,xy Sex Reversal 1
NCBI Summary:	This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome); translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome. [provided by RefSeq, Jul 2008]
UniProt Code:	Q05066
NCBI GenInfo Identifier:	548983
NCBI Gene ID:	6736
NCBI Accession:	Q05066.1
UniProt Related Accession:	Q05066
Molecular Weight:	23,884 Da
NCBI Full Name:	Sex-determining region Y protein
NCBI Synonym Full Names:	sex determining region Y
NCBI Official Symbol:	SRY
NCBI Official Synonym Symbols:	TDF; TDY; SRXX1; SRXY1
NCBI Protein Information:	sex-determining region Y protein
UniProt Protein Name:	Sex-determining region Y protein
UniProt Synonym Protein Names:	Testis-determining factor
Protein Family:	SRY-related protein
UniProt Gene Name:	SRY
UniProt Entry Name:	SRY_HUMAN