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Sry Antibody (PACO30136)

SKU:
PACO30136
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339
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Description

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Sry Antibody (PACO30136)

The SRY Polyclonal Antibody (PACO30136) is a valuable tool for researchers studying the SRY protein, a transcription factor involved in male sex determination and development. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the SRY protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it ideal for research in developmental biology and reproductive medicine.

SRY, or the sex-determining region Y protein, is a key player in the cascade of events that lead to the formation of male characteristics during embryonic development. Mutations or dysregulation of SRY can result in disorders of sex development and infertility, making it a crucial target for investigation. By studying SRY expression and function, researchers can gain insights into the molecular mechanisms underlying sex determination and potential therapeutic strategies for related conditions.

Antibody Name:Sry Antibody (PACO30136)
Antibody SKU:PACO30136
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Mouse
Immunogen:Recombinant Mouse Sex-determining region Y protein (1-143AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:Sex-determining region Y protein (Testis-determining factor), Sry, Tdf Tdy
UniProt Protein Function:SRY: Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. Defects in SRY are the cause of 46,XY sex reversal type 1 (SRXY1). A condition characterized by male-to-female sex reversal in the presence of a normal 46,XY karyotype. Patients manifest rapid and early degeneration of their gonads, which are present in the adult as 'streak gonads', consisting mainly of fibrous tissue and variable amounts of ovarian stroma. As a result these patients do not develop secondary sexual characteristics at puberty. The external genitalia in these subjects are completely female, and Muellerian structures are normal. A 45,X chromosomal aberration involving SRY is found in Turner syndrome, a disease characterized by gonadal dysgenesis with short stature, streak gonads, variable abnormalities such as webbing of the neck, cubitus valgus, cardiac defects, low posterior hair line. The phenotype is female. Defects in SRY are the cause of 46,XX sex reversal type 1 (SRXX1). A condition in which male gonads develop in a genetic female (female to male sex reversal). Belongs to the SRY family.Protein type: DNA-binding; Nuclear receptor co-regulatorCellular Component: cytoplasm; nucleusMolecular Function: calmodulin binding; DNA bending activity; DNA binding; protein binding; protein heterodimerization activity; transcription factor activityBiological Process: cell differentiation; male gonad development; male sex determination; negative regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; sex determination; sex differentiation; transcription, DNA-dependent
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q05738
NCBI GenInfo Identifier:6755761
NCBI Gene ID:21674
NCBI Accession:NP_035694.1
UniProt Secondary Accession:Q05738
UniProt Related Accession:Q05738
Molecular Weight:21.2 kDa
NCBI Full Name:sex-determining region Y protein
NCBI Synonym Full Names:sex determining region of Chr Y
NCBI Official Symbol:Sry  
NCBI Official Synonym Symbols:Tdf; Tdy  
NCBI Protein Information:sex-determining region Y protein
UniProt Protein Name:Sex-determining region Y protein
UniProt Synonym Protein Names:Testis-determining factor
Protein Family:Sex-determining region Y protein
UniProt Gene Name:Sry  
UniProt Entry Name:SRY_MOUSE

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