SRY Antibody (PACO02171)
- SKU:
- PACO02171
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
SRY Antibody (PACO02171)
The SRY Antibody (PACO02171) is a crucial tool for researchers studying the SRY protein, a key regulator of male sex determination and development. This polyclonal antibody is raised in rabbits and is highly specific for human samples, making it an ideal choice for Western blot applications. By targeting the SRY protein, this antibody enables precise detection and analysis in a variety of cell types, supporting research in developmental biology, reproductive health, and genetics.The SRY protein, also known as the sex-determining region Y protein, plays a critical role in initiating male-specific pathways during embryonic development.
Understanding the function and regulation of SRY is essential for unraveling the complexities of sex determination and differentiation, with implications for disorders of sexual development and infertility. The SRY Antibody (PACO02171) is a valuable asset for researchers investigating the molecular mechanisms underlying these processes and the potential therapeutic interventions for related conditions.
| Antibody Name: | SRY Antibody |
| Antibody SKU: | PACO02171 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | WB:1:500-1:2000 |
| Species Reactivity: | Human |
| Immunogen: | synthesized peptide derived from the Internal region of human SRY. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | SRY; TDF; Sex-determining region Y protein; Testis-determining factor |
| UniProt Protein Function: | SRY: Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. Defects in SRY are the cause of 46,XY sex reversal type 1 (SRXY1). A condition characterized by male-to-female sex reversal in the presence of a normal 46,XY karyotype. Patients manifest rapid and early degeneration of their gonads, which are present in the adult as 'streak gonads', consisting mainly of fibrous tissue and variable amounts of ovarian stroma. As a result these patients do not develop secondary sexual characteristics at puberty. The external genitalia in these subjects are completely female, and Muellerian structures are normal. A 45,X chromosomal aberration involving SRY is found in Turner syndrome, a disease characterized by gonadal dysgenesis with short stature, streak gonads, variable abnormalities such as webbing of the neck, cubitus valgus, cardiac defects, low posterior hair line. The phenotype is female. Defects in SRY are the cause of 46,XX sex reversal type 1 (SRXX1). A condition in which male gonads develop in a genetic female (female to male sex reversal). Belongs to the SRY family. |
| UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; DNA-binding Chromosomal Location of Human Ortholog: Yp11.3 Cellular Component: nucleoplasm; nucleus Molecular Function:DNA binding; RNA polymerase II transcription factor activity, enhancer binding; transcription factor binding Biological Process: positive regulation of transcription, DNA-dependent Disease: 46,xx Sex Reversal 1; 46,xy Sex Reversal 1 |
| NCBI Summary: | This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome); translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q05066 |
| NCBI GenInfo Identifier: | 548983 |
| NCBI Gene ID: | 6736 |
| NCBI Accession: | Q05066.1 |
| UniProt Related Accession: | Q05066 |
| Molecular Weight: | 23,884 Da |
| NCBI Full Name: | Sex-determining region Y protein |
| NCBI Synonym Full Names: | sex determining region Y |
| NCBI Official Symbol: | SRYÂ Â |
| NCBI Official Synonym Symbols: | TDF; TDY; SRXX1; SRXY1Â Â |
| NCBI Protein Information: | sex-determining region Y protein |
| UniProt Protein Name: | Sex-determining region Y protein |
| UniProt Synonym Protein Names: | Testis-determining factor |
| Protein Family: | SRY-related protein |
| UniProt Gene Name: | SRYÂ Â |
| UniProt Entry Name: | SRY_HUMAN |
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