The SRSF5 Antibody (PAC012149) is a polyclonal antibody specifically designed for research involving the splicing factor SRSF5. This antibody, developed and validated for use in Western blot applications, is highly reactive with human samples, allowing for precise detection and analysis of the SRSF5 protein in various cell types.SRSF5, a member of the serine/arginine-rich splicing factor family, plays a crucial role in alternative splicing of pre-mRNA molecules, thereby influencing gene expression and protein diversity. Dysregulation of splicing factors like SRSF5 has been implicated in various diseases, including cancer and neurodegenerative disorders.
With its high specificity and sensitivity, the SRSF5 Antibody (PAC012149) is a valuable tool for researchers interested in studying the role of SRSF5 in splicing regulation and its potential implications in disease development. By accurately targeting and detecting SRSF5, this antibody helps advance our understanding of RNA splicing mechanisms and their impact on cellular processes, paving the way for potential therapeutic interventions in the future.
SFRS5: Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Belongs to the splicing factor SR family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Spliceosome; RNA-binding; RNA processingChromosomal Location of Human Ortholog: 14q24Cellular Component: cytoplasm; nuclear speck; nucleolus; nucleoplasm; nucleusMolecular Function: protein bindingBiological Process: mRNA 3'-end processing; mRNA export from nucleus; mRNA processing; mRNA splice site selection; nuclear mRNA splicing, via spliceosome; RNA export from nucleus; termination of RNA polymerase II transcription
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
